ABSTRACT
To compare the extent and the degree of aggressiveness of inflammation on the total prostate specific antigen [t-PSA], free PSA [f-PSA], free / t-PSA ratio, and PSAD values in patients with chronic prostatitis. Retrospective, descriptive study. Yuksek Ihtisas Training and Research Hospital, Turkey. Fifty-five patients with serum t-PSA levels higher than 4 ng / ml and with chronic prostatitis were included. Transrectal ultrasound guided biopsy was taken from patients with serum PSA levels higher than 4 ng / ml. Histological sections of the prostatic tissues were scored using the extent and aggressiveness of inflammation seen, on a four point scale from 0 to 4. Serum PSA levels in different inflammation grades were compared. Kruskal-Walls variance analysis was used for inter-group assessment. In both groups scoring; no patient was in grade O. On the extent of inflammation group scoring; 2, 36, and 17 patients had grade 1, 2, 3, respectively. In this group, unlike the t-PSA values, the extent of inflammation was significant in PSA-D [p = 0.004] with a negative correlation in f / t PSA values. On the aggressiveness of inflammation group scoring; 18, 23, and 14 patients had grade 1, 2, 3, respectively. In this group, no statistical difference was found in terms of t-PSA, but statistical differences were monitored in terms of f-PSA, f / t PSA, and PSA-D values [p = 0.03, 0.002, 0.01, respectively]. High serum PSA levels in patients with asymptomatic chronic prostatitis may correlate with the degree of extent and aggressiveness of inflammation